Product ID:CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM, 250233
MSDS Date:02/22/1999
FSC:6550
NIIN:00N092483
Status Code:A
MSDS Number: CJSSV

Emergency Phone: 800-424-9300 (CHEMTREC)

Info Phone: 800-854-3417

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

CYTOCHALASIN B

CAS: 14930-96-2

RTECS: RO0205000

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL OR FATAL BY
INGESTION, INHALATION OR ABSORPTION THROUGH SKIN. MATERIAL MAY
CAUSE DAMAGE TO THE LIVER. CHRONIC: THERE IS LIMITED EVIDENCE THAT
CYTOCHALASIN B IS TERATOGENIC IN LAB ORATORY ANIMALS. THERE IS ALSO
LIMITED EVIDENCE THAT CYTOCHALASIN B IS MUTAGENIC IN LABORATORY
CELL CULTURES. UNTIL FURTHER TESTING HAS BEEN DONE, IT SHOULD BE
TREATED AS A POSSIBLE TERATOGEN AND MUTA GEN IN HUMANS.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:SKIN: WASH WITH SOAP AND COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND WASH
BEFORE WEARING. CONSULT A PHYSICIAN. EYES: FLUSH WITH COPIOUS
AMOUNTS OF WATE R FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING
BY SEPARATING THE EYELIDS WITH FINGERS. CONSULT A PHYSICIAN.
INHALATION: REMOVE TO FRESH AIR AND MONITOR BREATHING. IF BREATHING
BECOMES DIFFICULT, GIVE OXYGEN AND CONSULT A PHYSICIAN. IF
BREATHING STOPS, GIVE ARTIFICIAL RESPIRATION AND CONSULT A
PHYSICIAN. INGESTION: WASH MOUTH OUT WITH WATER AND CONSULT THE
LOCAL POISON CENTER AND A PHYSICIAN.

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
SELF-CONTAINED BREATHING RESPIRATOR, RUBBER BOOTS, AND HEAVY RUBBER
GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
DUST. HOLD FOR APPROPRIATE DI SPOSAL. WASH SPILL SITE AND VENTILATE
AREA AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A -20C FREEZER. PROTECT FROM LIGHT. MATERIAL IS TOXIC. POSSIBLE
TERATOGEN & MUTAGEN. AVOID CONTACT WITH MATERIAL. AVOID PROLONGED
OR REPEATED EXPOSURE. LAB SHOU LD BE EQUIPPED WITH A SAFETY SHOWER
& AN EYE WASH STATION. WASH THOROUGHLY AFTER HANDLING MATERIAL.
Other Precautions:MATERIAL SHOULD ONLY BE HANDLED BY QUALIFIED,
EXPERIENCED PROFESSIONALS.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
SHOWER .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
PHYSICAL/CHEMICAL PROPERTIES: SOLUBILITY: SOLUBLE IN DMSO AND ETHANOL.
MOLECULAR WEIGHT: 479.6. MOLECULAR FORMULA: C*29H*37NO*5.

Melt/Freeze Pt:>218.C, 424.4F
M.P/F.P Text:218C - 223C
Appearance and Odor:WHITE SOLID.

Stability Indicator/Materials to Avoid:YES
AVOID CONTACT WITH STRONG OXIDIZING AGENTS, STRONG ACIDS, AND STRONG
BASES.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE, AND NITROGEN
OXIDES.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE, & LOCAL REGULATIONS ARE
VARIED & CHANGE FREQUENTLY. FOR THIS REASON, MANUFACTURER
RECOMMENDS THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH
SERVICES FOR INFORMATION ON THE D ISPOSAL OF THIS PRODUCT/ARRANGE
FOR DISPOSAL BY A LICENSED DISPOSAL COMPANY. DISPOSE OF IN
ACCORDANC E WITH LOCAL, STATE, & FEDERAL REGULATIONS .

Toxicological Information:RTECS #: RO0205000. TOXICITY DATA &
REFERENCES: IPR; RAT; LD50: 11 MG/KG ATAXIA; COMA; CYANOSIS 1979.
TOXICON. 17, 137. IPR; MUS; LD50: 30 MG/KG 1979. FEDERATION
PROCEEDINGS, FEDERATION OF AMERICAN SO CIETIES FOR EXPERIMENTAL
BIOLOGY. 38, 438. REPRO EFTS & REFERENCES: ORL; MUS; DOSE: 1500
UG/KG MUSCULOSKETAL & CNS DEVEL ABNORMS 1987. TERATOLOGY,
INTERNATIONAL JOURNAL OF ABNORMAL DEVEL. 35, 87. IPR; HAM; DOSE: 5
MG/KG FETAL DEATH: CNS DEVEL ABNORMS 1980. TERATOLOGY,
INTERNATIONAL JOURNAL OF ABNORMAL DEVEL. 22, 59. GENETIC DATA &
REFERENCES: HLA; HMN; DOSE: 1 UMOL/L DNA INHIBITION 1982. MUTATION
RESEARCH. 92, 427. (OTHER INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE.

Transport Information:UN NUMBER: UN2811. PROPER SHIPPING NAME: TOXIC
SOLID, ORGANIC N.O.S.. IATA CLASS: 6.1. IATA PACKING GROUP: II.

Federal Regulatory Information:T. RISK PHRASES: R23/24/25: TOXIC BY
INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. R39: DANGER OF
VERY SERIOUS IRREVERSIBLE EFFECTS. R46: MAY CAUSE HERITABLE GENETIC
DAMAGE. R47: MAY CAUSE BIRTH DEFECTS. SAFETY PHRASES: S22: DO NOT
BREATHE DUST. S24/25: AVOID CONTACT WITH SKIN AND EYES. S36/37/39:
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION.
S45: IN CASE OF ACCIDENT OR I F YOU FEEL UNWELL, SEEK MEDICAL
ADVICE IMMEDIATELY. S53: AVOID EXPOSURE - OBTAIN SPECIAL
INSTRUCTION S BEFORE USE.
State Regulatory Information: